<p>There is provided a method of forming a multimeric complex having affinity for a target. The method comprises: obtaining a plurality of self-assembly molecules, said self-assembly molecules including complementary self-assembly units such as verotoxin subunit B, each of which is operatively connected to an interaction domain such as a single domain antibody specific for the target; and combining said self-assembly molecules such that at least three said self-assembly units simultaneously bind to one another so as to permit the single domain antibodies to bind the target.</p>
申请公布号
WO03046560(B1)
申请公布日期
2003.10.16
申请号
WO2002CA01829
申请日期
2002.11.29
申请人
NATIONAL RESEARCH COUNCIL OF CANADA;MACKENZIE, ROGER, C.;ZHANG, JIANBING