AGENT FOR PREVENTING OR TREATING DISEASES CAUSED BY ENOS EXPRESSION

摘要

To treat or prevent diseases and pathological conditions caused by the failu re of an eNOS gene expression product to exert the function inherent to eNOS, i t is intended to provide remedies of activating eNOS so as to its optimum function while having a high safety without any side effects. More specifically, drugs for treating or preventing diseases and pathological conditions caused by an increase in eNOS which comprise as the active ingredient the compounds represented by the following general formula or pharmaceutically acceptable salts thereof: (I) wherein R1 and R2 represent each hydrogen, or R1 and R2 together form a single bond; R3 represents - CH(OH)CH(OH)CH3, -CH(OCOCH3)CH(OCOCH3)CH3, -CH3, -CH2OH or phenyl provided that R1 and R2 each represents hydrogen, or R3 represents -COCH(OH)CH3 provided that R1 and R2 together form a single bond.