| 发明名称 |
USE OF IL-18 INHIBITORS |
| 摘要 |
The invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for the treatment and/or prevention of liver injury. The invention further relates to the use of IL-18 inhibitors in the preparation of a medicament for the treatment and/or prevention of arthritis, in particular rheumatoid arthritis. In addition to this, the invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for the treatment and/or prevention of inflammatory bowel diseases, in particular of Crohn's disease and ulcerative colitis. 52 claims, 19 figures
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| 申请公布号 |
BG107018(A) |
申请公布日期 |
2003.09.30 |
| 申请号 |
BG20020107018 |
申请日期 |
2002.08.20 |
| 申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.;YEDA RESEARCH AND DEVELOPMENT CO.LTD |
发明人 |
CHVATCHKO, YOLANDE;DINARELLO, CHARLES;PLATER-ZYBERK, CHRISTINE;VAN DEVENTER, SANTER;RUBINSTEIN, MENACHEM;NOVICK, DANIELA;KIM, SOO-HYUN |
| 分类号 |
C12N15/09;A61K31/00;A61K35/12;A61K38/00;A61K38/17;A61K38/21;A61K39/395;A61K45/00;A61K48/00;A61P1/04;A61P1/16;A61P19/02;A61P19/08;A61P25/32;A61P29/00;A61P31/12;A61P37/00;A61P37/02;A61P43/00;C07K16/24;C12N15/63;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/09 |
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