发明名称 |
SINGLE-STRANDED PROTEIN, MODULATOR OF LUTEINIZING, FOLLICLE-STIMULATING, THYROID-STIMULATING AND CHORIONIC GONADOTROPHIC HORMONES (VARIANTS), NUCLEIC ACID MOLECULE (VARIANTS), VECTOR (VARIANTS), STRAIN OF TRANSFORMED CELL CHO (VARIANTS), METHOD FOR PRODUCING SINGLE-STRANDED PROTEIN (VARIANTS) |
摘要 |
FIELD: biotechnology, endocrinology. SUBSTANCE: a single- stranded protein represents covalently bound alpha- and beta- or alpha- and alpha-, or beta- and beta- subunits of luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone and chorionic gonadotrophic hormone. Amino acid sequences of subunits bind through linker or without its. The complete link of CTP is used as a linker consisting of from 112-118 to 145 amino acid of human chorionic gonadotrophic hormone subunit. A single-stranded protein is prepared by culturing cell of the strain CHO transformed with vector comprising nucleic acid that encodes a single-stranded protein. Invention provides preparing stable forms of hormones. Invention can be used in preparing single-stranded forms of glycoprotein hormones. EFFECT: improved preparing method. 24 cl, 4 dwg, 4 ex
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申请公布号 |
RU2213099(C2) |
申请公布日期 |
2003.09.27 |
申请号 |
RU19960109046 |
申请日期 |
1995.08.01 |
申请人 |
VASHINGTON JUNIVERSITI |
发明人 |
BOIM IRVING |
分类号 |
C07K14/59;C12N5/10;C12N15/16;C12N15/63;C12P21/00;(IPC1-7):C07K14/59 |
主分类号 |
C07K14/59 |
代理机构 |
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地址 |
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