FUNCTIONAL MOLECULE AND PROCESS FOR PRODUCING THE SAME

摘要

It is intended to provide a process for producing a functional molecule which shows high affinities for various targets. Namely, a process for producing a functional molecule which involves the step of producing a modified oligonucleotide sequence wherein a modified nucleotide n-mer (n representing an integer) containing a modified nucleoside having a substituent transferred into a nucleoside constituting a nucleic acid is polymerized at random to give the modified oligonucleotide sequence. A preferable embodiment thereof comprises the selection step of selecting a modified nucleotide sequence having an affinity for a target from among the modified nucleotide sequences; the sequence-reading out step of amplifying the modified nucleotide sequence thus selected and determining its base sequence; and the translation step of translating the sequence of the modified oligonucleotide sequence having the thus determined base sequence based on the relation between at least one of 4<n> nucleotide n-mers and the modified nucleotide n-mer referring to a relation table showing one-to-one combinations of the 4 nucleotides.