USE OF ENZYME INHIBITORS WITH AMINOPEPTIDASE N AND/OR DIPEPTIDYLPEPTIDASE IV ACTIVITIES AND PHARMACEUTICAL PREPARATIONS PRODUCED THEREFROM FOR THE THERAPY AND PREVENTION OF DERMATOLOGICAL DISEASES WITH SEBORRHOEIC HYPERPROLIFERATION AND ALTERED DIFFERENTIATION STATES

摘要

The invention relates to a method for the inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells by the single or combined effect of inhibitors of alanylaminopeptidase (APN) and dipeptidylpeptidase IV (DP IV) expressed by said cells. DNA-synthesis (proliferation) of human sebaceous cells is inhibited by the administration of APN or/and DP IV in a dose-dependent manner. The invention is characterised in that the application of inhibitors of the above enzymes or corresponding preparations and dosage forms are suitable for the therapy and prevention of dermatological diseases with seborrhoeic proliferation and altered differentiation states.