发明名称 |
SUBTILISIN CARLSBERG PROTEINS WITH REDUCED IMMUNOGENICITY |
摘要 |
The present invention provides methods for the identification of CD4+ T-cell epitopes in subtilisin Carlsberg proteins. The present invention also provides for the production of altered peptides which, when incorporated into a wild-type subtilisin Carlsberg protein produce an altered immunogenic response, preferably a low immunogenic response in humans. In particular, the present invention provides means, including methods and compositions suitable for reducing the immunogenicity of ALCALASE(R) enzyme. |
申请公布号 |
WO03072746(A2) |
申请公布日期 |
2003.09.04 |
申请号 |
WO2003US05861 |
申请日期 |
2003.02.26 |
申请人 |
GENENCOR INTERNATIONAL, INC.;HARDING, FIONA, A |
发明人 |
HARDING, FIONA, A |
分类号 |
C12N5/08;C12N9/54;C12N9/56;C12N15/12;C12Q1/00;G01N33/50;G01N33/68 |
主分类号 |
C12N5/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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