USE OF THE PRION PROTEIN (PRP) FOR SUPPRESSION OF BAX-MEDIATED APOPTOSIS

摘要

The present invention relates to a method of protecting neurons against bax-mediated apoptosis and assays to identify agents which modulate neuron apoptosis. The present invention further relates to apoptosis modulation in other tissues in which prion protein is expressed, such as heart and lung. The invention further comprises a method of modulating apoptosis in a cell comprising an administration of an apoptosis-modulating effective amount of an agent which interferes with prion protein (PrP)-bax interaction.