Aromatic heterocycle compounds having HIV integrase inhibiting activities

摘要

A compound of the formula (I), a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof that has an inhibitory activity against an integrase is disclosed wherein: X is hydroxy, protected hydroxy or optionally substituted amino; Y is COORA wherein RA is hydrogen or ester residue, -CONRBRC wherein RB and RC each is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A1 is optionally substituted heteroaryl; provided that a compound wherein Y and/or A1 is optionally substituted indol-3-yl is excluded.