IMPROVEMENT IN THE PRODUCTION OF IMIDAZOLE DERIVATIVES AND NOVEL INTERMEDIATES OF THE DERIVATIVES

摘要

An improvement in the production of imidazole derivatives including histamine H3 agonist immepip and histamine H3 antagonist VUF4929. Desired imidazole derivatives can be easily obtained in high yield by using novel intermediates represented by the general formula (I): (I) wherein R1 is an amino-protecting group; R2 and R3 are each independently hydrogen, lower alkyl, or hydroxylated lower alkyl; R4 is lower alkyl, halogenated lower alkyl, or substituted or unsubstituted phenyl; and A is C1-3 alkylene.