发明名称 |
Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients |
摘要 |
Antibody-mediated xenograft rejection is attenuated by (1) removing preformed antibodies to various identified carbohydrate xenoantigens from the recipient's circulation prior to transplantation by extracorporeal perfusion of the recipient's blood over a biocompatible solid support to which the xenoantigens are bound and/or (2) parenterally administering a xenoantibody-inhibiting amount of an identified xenoantigen to the recipient shortly before graft revascularization and thereafter. |
申请公布号 |
US6607723(B1) |
申请公布日期 |
2003.08.19 |
申请号 |
US19950458683 |
申请日期 |
1995.06.02 |
申请人 |
ALBERTA RESEARCH COUNCIL;INTEGRIS BAPTIST MEDICAL CENTER, INC. |
发明人 |
GOOD A. HEATHER;COOPER DAVID K.C.;MALCOLM ANDREW J. |
分类号 |
A61K35/12;A61K35/14;A61K39/00;A61M1/36;A61P37/00;(IPC1-7):A61K34/385;C07K1/22;G01N33/53 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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