发明名称 |
Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use |
摘要 |
The invention provides twenty-one butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
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申请公布号 |
US2003153062(A1) |
申请公布日期 |
2003.08.14 |
申请号 |
US20010032233 |
申请日期 |
2001.12.20 |
申请人 |
WATKINS JEFFRY D.;PANCOOK JAMES D. |
发明人 |
WATKINS JEFFRY D.;PANCOOK JAMES D. |
分类号 |
A61K38/00;C12N9/18;(IPC1-7):C07H21/04;A61K38/46;C12N9/16 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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