发明名称 |
IMMUNE-MODULATING PEPTIDE |
摘要 |
Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds t o formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induc e degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.
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申请公布号 |
CA2446872(A1) |
申请公布日期 |
2003.08.07 |
申请号 |
CA20032446872 |
申请日期 |
2003.01.28 |
申请人 |
POSCO;POSTECH FOUNDATION |
发明人 |
RYU, SUNG-HO;SUH, PANN-GHILL;BAE, YOE-SIK;SONG, JI-YOUNG |
分类号 |
C12N15/09;A61K38/00;A61P1/00;A61P1/02;A61P1/04;A61P1/16;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P17/14;A61P19/02;A61P19/10;A61P25/00;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P35/00;A61P35/02;A61P37/06;C07K5/083;C07K5/107;C07K5/11;C07K7/06;(IPC1-7):C12N15/11;A61K38/06;A61K38/07;A61K38/08;C07K5/08;C07K5/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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