MODULATION OF T LYMPHOCYTES USING DP IV INHIBITORS

摘要

The present invention discloses a method for therapeutically treating mammals, including but not limited to humans, to modulate immune responses via modulation of surface expression of co-stimulatory antigens on T lymphocytes. oral administration of a DP IV inhibitor causes a potent immunosuppressive effect. This immunosuppressive effect of DP IV inhibitors is exerted by an enhancement of CTLA-4 surface expression, with simultaneous inhibition of CD28 surface expression, on T cells. Furthermore, the present invention discloses preparation of a medicament, comprising one or more inhibitors of dipeptidyl peptidase enzymatic activity, for the treatment of immune disorders such as allograft rejection or autoimmune disease.