CHIMERIC FLAVIVIRAL VACCINES

摘要

FIELD: medicine, virology, molecular biology. SUBSTANCE: invention relates to chimeric living infectious attenuated virus that is used for the development of chimeric flaviviral vaccines. Invention comprises chimeric living infectious attenuated virus including yellow fever virus where its nucleotide sequence encoding protein prM-E is deleted, truncated or mutated that results to block of expression of the functional protein prM-E. Also, genome of yellow fever virus comprises the incorporated nucleotide sequence encoding protein prM-E of the second distinguishing flavivirus such as that protein prM-E of the second flavivirus is expressed and nucleic acid molecule encoding this virus. The advantage of invention involves the development of chimeric viruses that can be used as living attenuated vaccines. EFFECT: valuable properties of vaccines. 18 cl, 7 dwg, 6 tbl