摘要 |
Potassium salt of (S)-omeprazole form B is prepared by converting (S)-omeprazole into the corresponding potassium salt in toluene or dichloromethane by treatment with a potassium source, such as potassium hydroxide or potassium methylate, followed by isolation of the formed salt. This salt can be used in the manufacture of pharmaceutical formulation for i.v. administration for treating gastrointestinal disorders. (S)-omeprazole is obtained by oxidizing 5-methoxy-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole, with an oxidizing agent and a chiral titanium complex, optionally in the presence of a base in an organic solvent, such as toluene or dichloromethane.
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