发明名称 |
PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, AND REFORMATSKY REAGENT IN STABLE FORM AND PROCESS FOR PRODUCING THE SAME |
摘要 |
A process for industrially advantageously producing a steroid C17,20-lyase inhibitor represented by the following general formula (I); and a Reformatsky reagent in a stable form which is suitable for use in the production process. Either a specific .szlig.-hydroxy ester compound derivative obtained from a specific carbonyl compound by the Reformatsky reaction or a salt of the compound is reduced in the presence of a metal/hydrogen complex compound and a metal halide and then subjected to ring closure to thereby obtain a compound represented by the general formula (I): (I) wherein the symbols have the same meanings as defined in the description. In the Reformatsky reaction, a stable solution of the compound represented by BrZnCH2COOC2H5 or crystals of the compound represented by (BrZnCH2COOC2H5.cndot.THF)2 are useful.
|
申请公布号 |
CA2472821(A1) |
申请公布日期 |
2003.07.24 |
申请号 |
CA20032472821 |
申请日期 |
2003.01.09 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
NAKAMOTO, KOJI;KAWAKAMI, JUN-ICHI;MIKI, SHOKYO;HANDA, SYOJI;NUWA, SHIGERU |
分类号 |
C07D233/64;A61K31/4164;A61K31/4188;A61P13/08;A61P15/00;A61P17/14;A61P35/00;A61P43/00;C07D213/55;C07D215/12;C07D233/54;C07D307/16;C07D307/33;C07D487/04;C07F3/06;(IPC1-7):C07D233/64;C07D497/04 |
主分类号 |
C07D233/64 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|