| 摘要 |
PURPOSE: Provided is a method for producing a cross-linking agent for bone filling using hyaluronic acid which is used for supplementation and substitution of bone in case of bone loss caused by periodontal diseases, dental surgical diseases and orthopedic surgical diseases. CONSTITUTION: The method includes the steps of (1) dissolving polyanionic polysaccharide in physiological saline in a concentration of 0.5 to 5 wt% to prepare a high viscosity solution; (2) adding an alginate to the solution from (1) in a concentration of 0 to 2.5 wt%, as needed, followed by stirring; (3) mixing bone powder with the solution from (2) while stirring; (4) treating the solution from (3) with a solution of a calcium salt; and (5) putting the product from (4) into a proper container. The polyanionic polysaccharide is one selected from hyaluronic acid, carboxymethyl cellulose, carboxymethyl amylose and derivatives thereof, or a mixture thereof.
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