Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia

摘要

This invention relates to a series of arylsubstituted piperazines, of Formula Ipharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the alpha-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.