发明名称 |
Microencapsulated plasminogen activators |
摘要 |
A drug delivery system which includes a plurality of microcapsules, each microcapsule containing a plasminogen activator entrapped in a biocompatible, biodegradable, substantially water-soluble polymeric matrix such that the plasminogen activator is releasable therefrom upon exposure of the microcapsules to an aqueous environment, as well as methods for preparing same. Methods of treating a thrombotic condition and reducing the time required for reperfusion of an occluded blood vessel are also described, which include parenterally administering to a mammal a therapeutically effective amount of a pharmaceutical composition which includes a plurality of such microcapsules.
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申请公布号 |
US6586011(B2) |
申请公布日期 |
2003.07.01 |
申请号 |
US20020176294 |
申请日期 |
2002.06.18 |
申请人 |
SOUTHPAC TRUST INTERNATIONAL, INC. |
发明人 |
LEACH JONATHAN K.;O'REAR EDGAR |
分类号 |
A61K9/16;A61K38/16;A61K38/49;(IPC1-7):A61K9/16;A61K9/50 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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