| 摘要 |
A heteroaromatic derivative or pharmaceutically acceptable salts thereof has the formula (I) R5-X-P(=O)(YR1)2 wherein: R5 is a group of formula (2); each G is independently selected from C, N, O, S, and Se, and wherein no more than one G is O, S, or Se, and at most one G is N; each G' is independently selected from C and N and wherein no more than two G' groups are N; X is a optionally substituted linking group that links R5 to the phosphorus atom via 2-4 atoms, wherein 0-1 atoms are heteroatoms selected from N, O, and S, and the remaining atoms are carbon, except that if X is urea or carbamate there are 2 heteroatoms, measured by the shortest path between R5 and the phosphorus atom, and wherein the atom attached to the phosphorus is a carbon atom, and wherein there is no N in the linking group unless it is connected directly to a carbonyl or in the ring of a heterocycle; and wherein X is not a 2 carbon atom -alkyl- or -alkenyl- group; with the proviso that X is not substituted with -COOR2, -SO3R1, or ?PO3(R1)2; Y is independently -O- or -NR6- and when Y is -O-, then R1 attached to -O- is independently -H, alkyl, optionally substituted aryl, alicyclic or -alkylaryl, -C(R2)2-OC(O)N(R2)2, -N(R2)2-C(O)-R3, -C(R2)2-OC(O)R3, -C(R2)2-O-C(O)OR3, -C(R2)2OC(O)SR3, alkyl-S-C(O)R3, -alkyl-S-S-alkylhydroxy, or -alkyl-S-S-S-alkylhydroxy and the cyclic moiety contains a carbonate or thiocarbonate, when Y is -NR6-, then R1 attached to -NR6- is independently -H, -[C(R2)2]q-COOR3, -C(R4)2COOR3, -[C(R2)2]q-C(O)SR3 or cycloalkylene-COOR3 or when either Y is independently -O- or -NR6-, then together R1 and R1 are -alkyl-S-S-alkyl- to form a cyclic group, or together R1 and R1 are a group of formula (3) and A, B, D, J, E, q, p, R6, R2, R3, R4, V, Z, W, and W' is as defined in the specification limited by the listed provisos. The compounds are useful in the treatment of diabetes and other conditions associated with elevated blood glucose or excess glycogen storage.
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