Kininogen fragment 2 peptides with the formula of at least X-His-Lys-X-Lys-X

摘要

A compound has the formula X1-His-Lys-X-Lys-X2 wherein X is any amino acid, X1 is a the segment His-Gly-His-Glu-Gln-Gln-His-Gly-Leu-Gly-His-Gly (SEQ ID NO:1) or a N-terminal truncation fragment containing at least one amino acid and X2 is zero amino acids or the segment Leu-Asp-Asp-Asp-Leu-Glu-His-Gln-Gly-Gly-His-Val (SEQ ID NO:2) or a C-terminal truncation fragment containing at least one amino acid. The compound may optionally comprise an amino-terminal and/or a carboxy-terminal protecting group. Also described are pharmaceutical compositions comprising the compounds with a pharmaceutically acceptable carrier.