发明名称 |
SUBSTITUTED 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-H-PHOSPHONATE AMMONIUM SALT AS SELECTIVE INHIBITORS OF PRODUCTION OF HUMAN IMMUNODEFICIENCY VIRUS HIV-1 AND HIV-2 |
摘要 |
FIELD: organic chemistry, medicine, virology. SUBSTANCE: invention relates to substituted 3'-azido-3'-deoxythymidine 5'-H-phosphonate ammonium salts of the general formula (I) where RR'R''N represent L-alanine, ethanolamine, triethanolamine, 6-aminocaproic acid, pyridoxylamine or dimethylaminoethanol that are selective inhibitors of production of human immunodeficiency virus HIV-1 and HIV-2. Compounds show the improved capacity to crystallization and less hygroscopicity as compared with 3'-azido-3'- -deoxythymidine with alkaline and earth-alkaline metal salts. EFFECT: improved properties of compounds. 3 tbl
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申请公布号 |
RU2207343(C2) |
申请公布日期 |
2003.06.27 |
申请号 |
RU19980119482 |
申请日期 |
1998.10.21 |
申请人 |
ZAKRYTOE AKTSIONERNOE OBSHCHESTVO "PROIZVODSTVENNO-KOMMERCHESKAJA ASSOTSIATSIJA AZT" |
发明人 |
KRAEVSKIJ A.A.;KONONOV A.V.;CHAGIR K.A. |
分类号 |
C07H19/06;A61K31/7072;A61P31/18;(IPC1-7):C07H19/06;A61K31/707 |
主分类号 |
C07H19/06 |
代理机构 |
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