PRODUCTION OF N-ACYLLYSOPHOSPHATIDYLCHOLINE COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING SAME FOR TREATMENT OF METABOLIC BONE DISEASE

摘要

PURPOSE: Provided is a process of preparing an N-acyllysophosphatidylcholine compound which is excellent in inhibition of differentiation of osteoclast cells and has no toxicity. A pharmaceutical composition containing the N-acyllysophosphatidylcholine compound is useful in the prevention and treatment of metabolic bone disease. CONSTITUTION: A pharmaceutical composition for the prevention and treatment of metabolic bone disease contains N-acyl-o-phosphocholine-L-serine methylester compound of formula(1) or a pharmaceutically acceptable salt thereof alone or together with a pharmaceutically acceptable carrier. In formula, R is C14-20 saturated for unsaturated fatty acid. The metabolic bone disease is any one selected from the group consisting of osteoporosis, bone metastatic cancer lesions, a tumor formed primarily in bones, rheumatoid or degenerative arthritis, periodontal disease, alveolar bone resorption disease, inflammatory bone resorption disease and Paget's disease.