| 摘要 |
<p>PURPOSE: A process for preparing beta-di-ribofuranose derivatives is provided, thereby preparing the high purity beta-di-ribofuranose derivatives useful as intermediates of ribavirin in higher yield. CONSTITUTION: A process for preparing beta-di-ribofuranose derivatives comprises reacting a compound of formula(2) and a compound of formula(3) in the presence of a catalyst selected from methane sulfonic acid, benzene sulfonic acid and para-toluene sulfonic acid at 80 to 120 deg. C, and crystallizing the reaction product in a solvent to prepare beta-di-ribofuranose derivatives of formula(1), wherein R1 is hydroxy protecting group; R2 is C1-C4 lower alkyl; and the crystallizing solvent is selected from the group consisting of methanol, ethanol, butanol, isobutanol, methanol solution, ethanol solution, butanol solution and isobutanol solution.</p> |
