| 摘要 |
A method and apparatus for controlling the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an anti-thermoregulatory response mechanism that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various anti-thermoregulatory response agents are disclosed including dopamine receptor blockers, dopamine receptor agonists, kappa opioid receptor agonists, mu opioid receptor agonists opioid agonist-antagonist analgesics, serotonin 5 HT1a agonists, alpha2-adrenorceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides. Specific examples of each are give. A control system for the control of the patient's temperature is disclosed for controlling the patient's temperature in conjunction with administering the anti-thermoregulatory response mechanism.
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