摘要 |
The invention provides the use of an aryl-substituted 1,1-diphosphonate for the manufacture of a medicament for stimulating bone formation; said aryl-susbtituted 1,1-diphosphonate being a compound of formula (I) in which A is (a) or (b) or (c) where: X<O> is H, an alkyl group having from 1 to 4 carbon atoms; X<1>, X<2> and X<3> are identical or different and are H, a straight or branched alkyl or alkoxy group having from 1 to 8 carbon atoms, X<4> is H, a straight or branched alkyl group having from 1 to 8 carbon atoms, an optionally substituted benzyl group, X<5> is H, a straight or branched alkyl group having from 1 to 8 carbon atoms, X<6> is H or an alkyl group having from 1 to 4 carbon atoms, q is 0 or 1, R<1>, R<2>, R<3> and R<4> are identical or different and are H, a straight, branched or cyclic alkyl group comprising from 1 to 8 carbon atoms, or R<1>, R<2> and R<3> and R<4> may form an alkylidenedioxy ring comprising from 2 to 8 carbon atoms, L is -CH=CH-CH2-, -(CH2)n, -O(CH2)n, -S-, -SO2, -S(CH2)n-, -SO2(CH2)n, where n is an integer from 1 to 7, or together with B, L is (CH=CH)k-(CH2)dCH=where k is 0 or 1 and d is an integrer from 0 to 4, -B is H, an alkyl group having from 1 to 4 carbon atoms, -t is 0 or 1, with the proviso that t is 0 only when L, together with B, is (CH=CH)k-(CH2)d-CH= where k and d are as described above, and with the further proviso that when L is -(CH2)n or -S-, at least one of R<1>, R<2>, R<3> and R<4> is other than hydrogen.
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