INDOLE-TYPE INHIBITORS OF P38 KINASE

摘要

The invention is directed to inhibition of p38- alpha kinase using compounds of formula (I) and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein Ar is an aryl group substituted with 0-5 non-interfering substituents, wherein two adjacent noninterfering substituents can form a fused aromatic or nonaromatic ring; L<1> and L<2> are linkers; X is an aliphatic monocyclic or aliphatic polycyclic moiety optionally comprising one or more hetero ring atoms wherein the cyclic moiety may be optionally substituted with one or more noninterfering substituents and where said optional substituents may constitute a ring fused to X; n is 0-3; each R<1> is hydrogen or a noninterfering substituent; (2) represents a single or double bond; one Z<2> is CA or CR<2>A; the other Z<2> is CR<3>, CR<3>2, NR<4> or N; and each R<2>, R<3> and R<4> is independently hydrogen or a noninterfering substituent; Z<3> is NR<5> or O; where R<5> is hydrogen or a noninterfering substituent.