| 摘要 |
<p>A novel process for producing a 1-H-1,2,4-triazole-3-carboxylic acid ester (compound I-1). The compound (I-1) is obtained by: deaminating 5-amino-1,2,4-triazole-3-carboxylic acid (I-2), halogenating the deaminated acid to obtain an acid chloride, and esterifying it; or esterifying the compound (I-2) and then deaminating it; or subjecting ethyl-ß-formyloxalylamidrazone to ring closure with the aid of a trialkyl orthoester and an acid. The compound (I-1) is an intermediate for the synthesis of a compound (I-13) (1-(substituted furan)-3-hydroxy-3-(1,2,4-triazole)propenone), which has anti-HIV activity. The process is hence extremely useful.</p> |
