| 摘要 |
This invention provides a compound comprising the structure: thetaalphaYDINYYTSbetalambd wherein each T represents a threonine, each S represents a serine, each Y represents a tyrosine; each D represents an aspartic acid, each I represents an isoleucine; and each N represents an asparagine; wherein alpha represents from 0 to 9 amino acids, with the proviso that if there are more than 2 amino acids, they are joined by peptide bonds in consecutive order and have a sequence identical to the sequence set forth in SEQ ID NO: 1 beginning with the I at position 9 and extending therefrom in the amino terminal direction; wherein beta represents from 0 to 14 amino acids, with the proviso that if there are more than 2 amino acids, they are joined by peptide bonds in consecutive order and have a sequence identical to the sequence set forth in SEQ ID NO: 1 beginning with the E at position 18 and extending therefrom in the carboxy terminal direction; wherein theta represents an amino group or an acetylated amino group; wherein lambd represents a carboxyl group or an amidated carboxyl group; wherein all of alpha,Y,D,I,N,Y,Y,T,S and beta are joined together by peptide bonds; further provided that at least two tyrosines in the compound are sulfated.
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