PROTEINS STABILIZED WITH POLYSACCHARIDE GUMS

摘要

Described are heat stable aqueous solutions or gels comprising a biologically effective amount of a protein and an effective stabilizing amount of a polysaccharide gum as well as heat stable solutions or gels suitable for use in an implantable drug delivery device at body temperature. Also disclosed are lyophilized compositions having biologically activity, where such lyophilized compositions are formed by lyophilozing the stabilized solutions or gels of the invention. Such lyophilized powders can be used after reconstitution with an amount of aqueous that provide an effective stabilizing concentration of polysaccharide and a pharmaceutically acceptable amount of therapeutic protein particularly against thermal and oxidative stress.