METHODS FOR INHIBITING LENTIVIRUS REPLICATION

摘要

The present invention provides screening methods for identifying a compound that induces loss of the lentiviral protein Vpr screening methods for identifying compounds that inhibit the peptidyl-prolyl cis/trans isomerase PPIase activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr and compounds identified by the screening methods. The compounds are useful for treating a lentiviral infection. The present invention further provides methods of inducing loss of the lentiviral protein Vpr methods of inhibiting lentivirus viral replication and methods of treating a lentivirus infection in an individual. The methods generally involve administering to an individual infected with the lentivirus an effective amount of a compound that induces Vpr loss and/or that inhibits PPIase activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr.