发明名称 |
BICISTRONIC INFLUENZA VIRUSES COMPRISING TWO GENES IN TANDEM |
摘要 |
<p>The invention relates to recombinant influenza viruses for high-yield expression of incorporated foreign gene(s), which are genetically stable in the absence of any helper virus and which comprise at least one viral RNA segment being a tandem bicistronic RNA molecule coding for two genes in tandem, in said tandem bicistronic RNA molecule one of the standard viral genes being in covalent junction with a foreign, recombinant gene and having an upstream splice donor and a downstream splice acceptor signal surrounding the proximal coding region. The invention further provides a method for obtaining attenuated viruses which resist reassortment dependent progeny production in case of chance superinfections by wild-type influenza viruses; a method for the production of said recombinant influenza viruses; pharmaceutical compositions comprising said recombinant influenza viruses; and the use of said recombinant influenza viruses for preparing medicaments for vaccination purposes.</p> |
申请公布号 |
EP1301616(A2) |
申请公布日期 |
2003.04.16 |
申请号 |
EP20010967171 |
申请日期 |
2001.07.13 |
申请人 |
ARTEMIS PHARMACEUTICALS GMBH |
发明人 |
HOBOM, GERD;MENKE, ANETTE;MEYER-ROGGE, SABINE |
分类号 |
C12N15/09;A61K31/7105;A61K39/00;A61K39/145;A61K48/00;A61P31/16;A61P37/02;C07K14/11;C12N7/00;C12N7/04;C12N15/86;(IPC1-7):C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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