| 摘要 |
Production of enolates of substituted alpha -ketoesters comprises reaction of oxalic acid diesters with CH acid compounds in the presence of alcoholates using a 4-8C ether solvent. Production of enolates of substituted alpha -ketoesters of formula (I) comprises reaction of oxalic acid diesters of formula (II) with CH acid compounds of formula (III) in the presence of alcoholates of formula MOR<5> (4) using a 4-8C ether solvent. R<1>, R<2> = H, COOR, C(O)R, CN, CONHR or CONR2; R = 1-20C alkyl (optionally branched or cyclic), 6-10C aryl or an aralkyl having an R group (alkyl and aryl groups are optionally substituted by heteroatoms); R<3>, R<4> = R; M = alkali or alkaline earth metal; and R<5> = alcoholic residue of an optionally branched or cyclic aliphatic 1-6C monoalcohol; Provided that both R<1> and R<2> are not H.
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