发明名称 |
Synthetic HIV-2 envelope genes containing modifications that lead to optimized expression in bacteria |
摘要 |
The present invention provides a method of synthesizing genes encoding unique HIV-1 and HIV-2 envelope proteins and their fragments, thereby allowing overexpression of these proteins in E. coli. The HIV envelope proteins and their fragments have been expressed at high levels as individual proteins or in fusion with other proteins. The HIV envelope proteins thus expressed in E. coli can be effectively used for the detection of exposure to HIV as well as the discrimination of HIV-1 and HIV-2.
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申请公布号 |
US6538127(B1) |
申请公布日期 |
2003.03.25 |
申请号 |
US19950443530 |
申请日期 |
1995.05.18 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
DEVARE SUSHIL G.;CASEY JAMES M.;DESAI SURESH M. |
分类号 |
G01N33/569;A61K39/21;C07K1/00;C07K14/00;C07K14/155;C07K14/16;C07K14/195;C07K14/41;C07K14/705;C07K19/00;C12N9/00;C12N15/09;C12N15/48;C12P21/02;C12R1/19;(IPC1-7):C07H21/04 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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