发明名称 |
ENHANCEMENT OF ORAL BIOAVAILABILITY OF NON-EMULSIFIED FORMULATION OF PRODRUG ESTERS WITH LECITHIN |
摘要 |
A method for enhancing the oral bioavailability of a prodrug ester by formulating the ester as non-emulsified formulation with lecithin; as well as a pharmaceutical composition of at least one antibiotic and lecithin in a non-emulsified formulation; a method of treating infections with the non-emulsified formulation, and a method for preparing tablets by direct compression of blends of drugs with lecithin are disclosed. Non-emulsified formulations include solids, tablets, capsules, lozenges, suspensions, elixirs and solutions, and exclude emulsions, liposomes, lipid matrix systems and micro-emulsions. A suitable prodrug ester is a cephalosporin ss-lactam antibiotic such as cefditoren pivoxil, and a suitable non-emulsified formulation is a solid formulation. |
申请公布号 |
WO02096354(A3) |
申请公布日期 |
2003.03.20 |
申请号 |
WO2002US16428 |
申请日期 |
2002.05.28 |
申请人 |
TAP PHARMACEUTICAL PRODUCTS INC. |
发明人 |
TANEJA, RAJNEESH;BRINKER, DALE;BRISKIN, JACQUELINE;VISHWASRAO, DILIP;APONTE, ROBERTO;GUPTA, PRAMOD |
分类号 |
A61K9/10;A61K9/00;A61K9/16;A61K9/20;A61K31/343;A61K31/4375;A61K31/545;A61K31/546;A61K31/56;A61K31/65;A61K31/7048;A61K45/00;A61K47/02;A61K47/24;A61K47/26;A61K47/36;A61P31/04;A61P43/00 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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