发明名称 |
Inhibitors of prenyl-protein transferase |
摘要 |
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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申请公布号 |
US6525074(B2) |
申请公布日期 |
2003.02.25 |
申请号 |
US20010757251 |
申请日期 |
2001.01.09 |
申请人 |
MERCK & CO., INC. |
发明人 |
DESOLMS S. JANE;MACTOUGH SUZANNE C.;SHAW ANTHONY W. |
分类号 |
A61P35/00;C07D403/04;C07D413/04;C07D419/04;(IPC1-7):C07D498/18;A61K31/417;A61K31/440 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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