RECOMBINANT PRODUCTION OF NEW POLYKETIDES

摘要

PROBLEM TO BE SOLVED: To provide new polyketides and a new method for efficiently producing both new and known polyketides by using a recombinant technology. SOLUTION: A new host-vector system which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides is described. Accordingly, one aspect of the invention is directed to a genetically engineered cell which expresses a polyketide synthase(PKS) gene cluster in its native, nontransformed state and the genetically engineered cell substantially lacks the entire native PKS gene cluster.