| 摘要 |
Imidazolyl alkyl aryl alkanoic acid derivatives (I), their tautomers, enantiomers, diastereoisomers, and epimers, and their salts. Imidazolyl alkyl aryl alkanoic acid derivatives (I), their tautomers, enantiomers, diastereoisomers, and epimers, and their salts. X = CH, N, O or S, and each is independent of the others; R1, R2, R3, R4 and R5 = 1-20C alkyl, (optionally substituted by halogen, 1-5C alkyl, 3-8C cycloalkyl, 1-5C alkoxy, amino, substituted amino, carbonyl, ester, amide, O, S, or P), 2-20C alkylene or alkyne (both optionally substituted by halogen, 1-5C alkyl or alkoxy, or 3-8C cycloalkyl), 3-8C cycloalkyl (optionally substituted by 1-5C alkyl or alkoxy), 3-8c heterocycloalkyl (having 1-3 hetero atoms (O, N, S)and optionally substituted by 1-5C alkyl or alkoxy), 6-14C aryl 3-8C alkyl (optionally substituted by amino, OH, SH, halogen, 1-5C alkyl, alkoxy, alkylthio or alkylamino, 6-14C aryl, aryl 1-5C sulfonylalkyl, aryloxy, aryl 1-5C alkoxy, CN, CF3, carboxy as the free acid or ester, carboxymethyl or carboxyethyl), 6-14C aryl (optionally substituted by amino, OH, SH, halogen, 1-5C alkyl, alkoxy, alkylthio or alkylamino, 6-14C aryl, aryl 1-5C sulfonylalkyl, aryloxy, aryl 1-5C alkoxy, CN, CF3, carboxy, carboxymethyl or carboxyethyl), or 1-13C heteroaryl (containing one or more heteroatoms (O, N, S) and optionally substituted by amino, OH, SH, halogen, 1-5C alkyl, alkoxy, alkylthio or alkylamino, 6-14C aryl, aryl 1-5C sulfonylalkyl, aryloxy, aryl 1-5C alkoxy, CN, CF3, carboxy, carboxymethyl or carboxyethyl); A = 1-6C alkyl (optionally substituted by halogen, 3-8C cycloalkyl, 1-5C alkoxy, amino, substituted amino, ester, amide, O, S, or P); B' = a bond or 1-6C alkyl (optionally substituted by halogen, 3-8C cycloalkyl, 1-5C alkoxy, amino, substituted amino, ester, amide, O, S, or P) except for those compounds of formula (I) in which R1 = R2 = H, R3 = H or CH3, R4 = H or -NH-CH2-C6H5, R5 = H, A = CH2, and B is a bond.
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