SOLUBLE STEROIDAL PEPTIDES FOR NUCLEIC ACID DELIVERY
摘要
Amphiphilic lipopeptide compositions for gene delivery are disclosed. An illustrative amphiphilic lipopeptide composition includes a human protamine 2 peptide conjugated to a hydrophobic moiety. Illustrative hydrophobic moieties include sterols, bile acids, and fatty acids. The amphiphilic lipopeptide composition is mixed with a nucleic acid such that the nucleic acid binds to the peptide portion of the lipopeptide. This mixture is placed in contact with mammalian cells to effect transfection of the cells with the nucleic acid. A method of making such amphiphilic lipopeptides is also described.
申请公布号
WO03004685(A2)
申请公布日期
2003.01.16
申请号
WO2002US21265
申请日期
2002.07.03
申请人
UNIVERSITY OF UTAH RESEARCH FOUNDATION;MAHATO, RAM, I.;MAHESHWARI, ANURAG;KIM, SUNG, WAN