发明名称 |
PHOSPHOROTHIOATE ANTISENSE HEPARANASE OLIGONUCLEOTIDES |
摘要 |
The present invention provides antisense phosphorothioate oligonucleotides that specifically inhibit the translation of heparanase. The invention also provides various methods of reducing angiogenesis and metastasis of tumors in a subject using said antisense phosphorothioate oligonucleotides. Finally the invention provides pharmaceutical compositions comprising the said antisense phosphorothioate oligonucleotides as active ingredients.
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申请公布号 |
WO03004705(A1) |
申请公布日期 |
2003.01.16 |
申请号 |
WO2002US20636 |
申请日期 |
2002.07.01 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK;STEIN, CY |
发明人 |
STEIN, CY |
分类号 |
C12N15/113;(IPC1-7):C12Q1/68;C07H21/00 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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