发明名称 |
METHOD OF INHIBITING PTP 1B AND/OR T-CELL PTP AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 |
摘要 |
This invention relates to oxalylamide inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B) and/or T-cell Protein Tyrosine Phosphatase (TC-PTP) and/or Protein Tyrosine Phosphatases (PTPases) having an aspartic acid (Asp) in position 48 (PTP1B numbering, Chernoff et al., Proc. Natl. Acad. Sci. USA 87: 2735-2789 (1989)) and a method of inhibiting such PTPases by exposing the enzyme to inhibitor compounds of formula 1. This invention also relates to (I) the design and selection of inhibitors, which bind to the active site of PTP1B and/or TC-PTP and/or PTPases having an aspartic acid (Asp) in position 48 (II) the synthesis of said inhibitors, methods for their preparation and (III) to compositions comprising the inhibitor compounds.
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申请公布号 |
WO03002569(A1) |
申请公布日期 |
2003.01.09 |
申请号 |
WO2002DK00425 |
申请日期 |
2002.06.25 |
申请人 |
NOVO NORDISK A/S |
发明人 |
HANSEN, THOMAS, KRUSE;OLSEN, OLE, HVILSTED;PETERSEN, ANDERS, KLARSKOV;LAU, JESPER;ANDERSEN, HENRIK, SUNE;MOELLER, NIELS, PETER, HUNDAHL |
分类号 |
A61K31/439;A61K31/5383;A61K31/55;A61P3/04;A61P3/10;A61P5/00;A61P7/04;A61P19/10;A61P25/28;A61P35/00;A61P37/02;A61P37/08;C07D495/18;C07D498/18;(IPC1-7):C07D495/08;C07D498/08;A61K31/436;A61K31/437;A61K31/536 |
主分类号 |
A61K31/439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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