| 发明名称 |
Process for crystallisation of losartan |
| 摘要 |
<p>Losartan potassium is an angiotensin II antagonist useful in the treatment of hypertension and congestive heart failure (I). This invention relates to the process for the controlled crystallisation of losartan potassium utilising anti-solvent addition combined with massive seeding in order to obtain the desired crystal morphology and bulk physical properties necessary for successful formulation.</p> |
| 申请公布号 |
SK282875(B6) |
申请公布日期 |
2003.01.09 |
| 申请号 |
SK19990000570 |
申请日期 |
1997.10.24 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
BREEN PATRICK;DIENEMANN ERIK A.;EPSTEIN ALBERT D.;LARSON KAREN A.;KENNEDY MICHAEL T.;MAHADEVAN HARI |
| 分类号 |
C07D403/10;(IPC1-7):C07D403/10 |
主分类号 |
C07D403/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
