| 摘要 |
The invention relates to the chemistry of biologically active compounds, namely, to a new method to prepare water-soluble porphyrin derivatives, particularly chlorin derivatives having general formulae (1). The compounds of the present invention are useful as photosensitizers for the photodynamic therapy of cancer, of infectious and other diseases, as well as for light irradiation treatments in other cases. where: R1=-CH=CH2, -CH(OAlk)CH3, -CHO, -C(O)CH3; -CH2CH3; -CH(Alk)CH(COAlk)2, -CH2CH(COAlk)2, -CH(Alk)CH2COAlk, -CH(Alk)CH2CH(OH)CH3, -CH2CH2CH(OH)CH3 R2=-CH3, -CHO, -CH(OH)Alk, -CH=CHAlk, CH2OH, CH2OAlk; R3=H or lower allyl; G=hydrophilic organic amine (f. ex. N-methyl-D-glucamine and other amino-group containing carbohydrate derivatives, TRIS, aminoacids, oligopeptides). Alk=alkyl substituent. |
