Use of new and known imidazole derivatives as sodium channel modulators used for treating e.g. pain, epilepsy, cardiac rhythm disorders, neurodegeneration, depression, irritable bowel syndrome, and diabetic retinopathies

摘要

Use of imidazole derivatives (I) or their salts is claimed for modulating sodium channels. The use of imidazole derivatives (I) or their salts is claimed for modulating sodium channels. R<1> = 3-16C alkyl, (3-7C) cycloalkyl (1-6C) alkyl or aralkyl (optionally aryl substituted by 1-3 halo, 1-6C alkyl or 1-6C alkoxy); R<2> = phenyl (optionally substituted by 1-3 halo, 1-6C alkyl or 1-6C alkoxy) or biphenyl (optionally substituted by 1-4 halo, 1-6C alkyl or 1-6C alkoxy), and R<3> = H or 1-6C alkyl. An Independent claim is also included for new compounds (I) and their salts, provided that when R<2> is optionally substituted phenyl, then R<1> is not 1-6C alkyl or a group of formula (i). R<9> = H, halo, 1-6C alkyl or 1-6C alkoxy; n = 1-3; R<10>, R<11> = H or 1-6C alkyl provided that when R<2> is unsubstituted biphenyl or optionally substituted phenyl, then R<1> is not (CH2)n1-Z, where: n1 = 0-3, and Z = 1-4C alkyl or phenyl or naphthyl optionally substituted by 1-3 halo or 1-4C alkoxy.