Verfahren zur Herstellung von Cyclohexylazetidinon

摘要

To synthesise an intermediate product (IV) for antibacterial tricyclic beta -lactam compounds, (2S)-2-methoxycyclohexanone is first reacted with a magnesium amide of the formula R3R4NMgX in order to obtain a magnesium enolate derivative. The latter is then condensed with acyloxyazetidinone to obtain the intermediate product (IV). The intermediate (IV) thus obtained can be transformed into tricyclic beta -lactam compound (VI). The process has the advantages of not using Lewis acid and simplifying the production process of tricyclic beta -lactam compounds.