发明名称 |
MOLECULAR CLONES WITH MUTATED HIV GAG/POL, SIV GAG AND SIV ENV GENES |
摘要 |
<p>Nucleic acid constructs containing HIV-1 <i>gag/pol</i> and SIV <i>gag</i> or SIV <i>env</i> genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified constructs and viral particles of the invention may be useful in gene therapy for numerous disorders, including HIV infection, or as a vaccine for HIV-1 immunotherapy and immunoprophylaxis.</p> |
申请公布号 |
WO02099101(A1) |
申请公布日期 |
2002.12.12 |
申请号 |
WO2002US17258 |
申请日期 |
2002.05.31 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;PAVLAKIS, GEORGE, N. |
发明人 |
PAVLAKIS, GEORGE, N. |
分类号 |
C12N15/09;A61K31/7052;A61K39/00;A61K39/21;A61K48/00;A61P31/18;A61P37/04;C07K14/155;C07K14/16;C12N1/21;C12N5/08;C12N5/10;C12N7/00;C12N15/867;(IPC1-7):C12N15/00;C12N15/63 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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