摘要 |
It has been confirmed that antitumor agents containing as the active ingredient (3R)-N-(1-(1-tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2- pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea favorably inhibit the proliferation of cancer in various cancer-carrying mice and have a low toxicity. These agents are particularly useful in treating pancreatic cancer, intestinal cancer and gastric cancer. In case of using these drugs i n polypharmaceutical chemotherapy, the administration dose of an antitumor age nt having strong side effects can be lowered. It is therefore expected that polypharmaceutical chemotherapy achieving a favorable antitumor effect and relieved side effects can be thus embodied.
|