| 摘要 |
Peptide derivatives (I), their tautomers, stereoisomers (or mixtures) and salts. Peptide derivatives of formula (I), their tautomers, stereoisomers (or mixtures) and salts are new. A = aryl, 3-8C cycloalkyl or cycloalkenyl, optionally fused to phenyl (all optionally substituted by 1-5 halo, OH, SH, CN, CF3, formyl, 1-8C alkylcarbonyl, carboxy, 1-4C alkoxycarbonyl, COOH, 1-4C alkylcarbonyloxy, 1-16C alkyl, 1-8C alkoxy (optionally substituted by 1-8C alkyl), 1-8C alkyl (substituted by 1-8C alkoxy), formyl, or 1-8C alkylcarbonyl), NO2, amino or carboxamido (both optionally substituted by 1-2 1-4C alkyl), 1-4C alkylcarbonylamino, also, for at least partly saturated rings, oxo, and all substituents other than oxo may be present on fused phenyl; D = O or S(O)x; x = 0-2; X = O, S or NR3; R1-R3 = H, 1-16C alkyl, 1-8C alkoxy, 1-8C alkylcarbonyl, 1-4C alkoxycarbonyl, 1-4C alkylcarbonyloxy, 1-8C alkoxy optionally substituted by 1-8C alkyl, 1-8C alkyl substituted by 1-8C alkoxy, formyl, or 1-8C alkylcarbonyl, NO2, amino or carboxamido (both optionally substituted by 1-2 1-4C alkyl), 3-5C cycloalkyl, aryl or benzyl; Y = aryl, 3-8C cycloalkyl or cycloalkenyl, (all of which may be substituents on 1-8C alkyl, alkoxy or 1-8C alkylcarbonyl), all optionally fused to phenyl and optionally substituted as specified for A; E, Z = H, halo, OH, SH, CF3, CN, formyl, 1-8C alkylcarbonyl, carboxy, 1-4C alkoxycarbonyl, COOH, 1-4C alkylcarbonyloxy, 1-16C alkyl, 1-8C alkoxy optionally substituted by 1-8C alkyl, 1-8C alkyl substituted by 1-8C alkoxy, formyl, or 1-8C alkylcarbonyl, NO2, amino or carboxamido (both optionally substituted by 1-2 1-4C alkyl), 1-4C alkylcarbonylamino, aryl, 3-8C cycloalkyl or cycloalkenyl, or 8-12C bicycloalkyl (the last four groups may be linked through CO, 1-8C alkyl, alkoxy, or alkylcarbonyl, aminocarbonyl or 1-8C alkylaminocarbonyl), where all rings may be fused to phenyl and optionally substituted as for A.
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