发明名称 |
Recombinant vaccinia virus incorporated with gene coding glutamic acid decarboxylase and vaccine for preventing type 1 diabetes mellitus comprising the same |
摘要 |
A vaccine including recombinant vaccinia virus (ATCC VR-1354) having an inserted gene for coding glutamic acid decarboxylase is used for preventing type 1 diabetes mellitus. The glutamic acid decarboxylase expressed from the recombinant virus suppresses or tolerizes the autoreactive T cell, and induces immunological tolerance, thus effectively prevents or delays the development of type 1 diabetes mellitus.
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申请公布号 |
US2002155596(A1) |
申请公布日期 |
2002.10.24 |
申请号 |
US20010995829 |
申请日期 |
2001.11.29 |
申请人 |
KOREA GREENCROSS CORPORATION |
发明人 |
YOON JI WON;JUN HEE-SOOK |
分类号 |
C12N15/86;A61K39/00;C12N9/88;(IPC1-7):C07H21/04;A61K39/12;A61K39/275;A61K39/285;C12N7/00;C12N7/01;C12N15/00;C12N15/63;C12N15/70;C12N15/74;C12N15/09 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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地址 |
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